GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs5770917 | 1 | rs5770911 | chr22:51011241 | ARSA | chr22:51063450-51066607:- | 0.3 | 3.41 | 0.000704 | Narcolepsy |
| THCA | cis | rs5770917 | 1 | rs5770911 | chr22:51011241 | CHKB | chr22:51017378-51021428:- | 0.46 | 5.07 | 5.64E-7 | Narcolepsy |
| THCA | cis | rs5770917 | 1 | rs5770911 | chr22:51011241 | CPT1B | chr22:51007291-51017096:- | -0.39 | -7.28 | 1.43E-12 | Narcolepsy |
| THCA | cis | rs5770917 | 1 | rs5770917 | chr22:51017353 | CHKB | chr22:51017378-51021428:- | 0.43 | 4.87 | 1.55E-6 | Narcolepsy |
| THCA | cis | rs5770917 | 1 | rs5770917 | chr22:51017353 | CPT1B | chr22:51007291-51017096:- | -0.35 | -6.61 | 1.04E-10 | Narcolepsy |
| THCA | cis | rs5770917 | 1 | rs5770922 | chr22:51023408 | ARSA | chr22:51063450-51066607:- | 0.31 | 3.44 | 0.000622 | Narcolepsy |
| THCA | cis | rs5770917 | 1 | rs5770922 | chr22:51023408 | CHKB | chr22:51017378-51021428:- | 0.45 | 4.92 | 1.2E-6 | Narcolepsy |
| THCA | cis | rs5770917 | 1 | rs5770922 | chr22:51023408 | CPT1B | chr22:51007291-51017096:- | -0.38 | -7 | 8.45E-12 | Narcolepsy |
| THCA | cis | rs5770917 | 1 | rs5770924 | chr22:51024542 | CHKB | chr22:51017378-51021428:- | 0.41 | 4.49 | 8.77E-6 | Narcolepsy |
| THCA | cis | rs5770917 | 1 | rs5770924 | chr22:51024542 | CPT1B | chr22:51007291-51017096:- | -0.37 | -6.81 | 2.91E-11 | Narcolepsy |
| THCA | cis | rs477692 | 1 | rs577227 | chr10:131404528 | MGMT | chr10:131265454-131565783:+ | 0.38 | 11.47 | 4.41E-27 | Response to temozolomide |
| THCA | cis | rs73201462 | 1 | rs57735707 | chr3:128065815 | EEFSEC | chr3:127872313-128127488:+ | -0.22 | -3.79 | 0.000173 | Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio |
| THCA | cis | rs7107174 | 1 | rs57738705 | chr11:77994489 | NARS2 | chr11:78147017-78285909:- | -0.38 | -6.98 | 1.02E-11 | Testicular germ cell tumor |
| THCA | cis | rs2129782 | 1 | rs57771217 | chr8:89411860 | MMP16 | chr8:89049462-89339717:- | 0.31 | 5.04 | 6.5E-7 | Electrodermal activity |
| THCA | cis | rs9813712 | 1 | rs57804141 | chr3:129962512 | COL6A4P2 | chr3:129931663-129992648:+ | 0.24 | 4.63 | 4.81E-6 | Response to amphetamines |